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Glioblastoma

Glioblastoma (GBM) is the most frequent malignant primary brain tumor. Studying its
invasive behavior in vitro could help disease prognosis and making a therapeutic decision in a
timely manner. The current state of the art is to inject patient-derived GBM cells into mouse brain
and study the outcome. While this approach provides useful insights, it is time consuming and
may not sufficiently recapitulate the actual cellular pathologies occurring in the human brain.
This gap is now being filled with the application of induced Pluripotent Stem Cells (iPSC)-derived
3D-brain organoids “Brains in a dish” that recapitulate many features of the complex human
brain tissue. Recently, we established a 3D GBM invasion assay using human brain organoids,
in which we analyze the invasive behavior of patient-derived GBM cells. Successfully
establishing an autologous GBM invasion assay will help assessing the invasive behavior and
neurotoxicity of an individualized GBM and lay foundations for a precision medicine model for
testing drugs against tumor invasion.

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